Heptest FIBRINOTEST-Equine
Fast, simple, accurate, automated, cost-effective...
FIBRINOTEST-Equine point-of-care, whole blood
fibrinogen testing with results in less than two minutes
Heptest Laboratories, Inc. of St. Louis, MO - an industry leader in clotting assays and coagulation products, is proud to introduce the newest product in their line of coagulation assays - the FIBRINOTEST-Equine. This new, easy-to-use, point-of-care assay allows the veterinarian to run fibrinogen tests instantly in their clinic or in the field, using just 500 micro liters of whole blood, with results delivered in less than two minutes.
Extensively researched and tested using actual equine patients, the FIBRINOTEST-Equine highly correlates to the current "gold standard" laboratory assay for fibrinogen, the modified Clauss (plasma test), yet is more sensitive, fully automated and simple for anyone to use on-site. No more need to send blood samples off to a commercial laboratory, incurring additional costs and time delays that can be critical to optimum patient diagnosis and care.
FIBRINOTEST-Equine is both cost-effective and easy to use. The simple test can be run using the same inexpensive clot detectors used with the Equine Coagulation Management System (ECMS) available from Heptest Laboratories - in the clinic or in the field. There is no need for time consuming steps such as centrifuging and component mixing - just simply draw a citrated vacutainer of whole blood from the patient, draw up 500 micro liters of the citrated whole blood with the automatic pipettor, place the sample in the FIBRINOTEST-Equine assay vial, mix for 6 seconds, drop the vial into the testing machine, and in less than two minutes you will be given the thrombin clottable fibrinogen in mg/dL of whole blood. It is that simple, and that quick.
There are many reasons for an equine practitioner to incorporate fibrinogen testing into their diagnostic routine. Fibrinogen is a soluble plasma protein that is converted by thrombin into fibrin during blood coagulation (clotting). In equine medicine, fibrinogen is used as a marker, with elevated levels indicating a degree of systemic inflammatory response, often occurring before any clinicial signs of disease are present. Low levels of fibrinogen can indicate a systemic activation of the clotting system leading to "DIC". While DIC can be difficult to diagnose, a strong clue is low fibrinogen levels in the setting of prolonged clotting times, in the context of acute critical illness such as sepsis or trauma.
FIBRINOTEST-Equine is 2-3 times more sensitive to fibrinogen than the original Clauss assay. This makes it possible to test for very low levels of fibrinogen in patients such as those with congenital fibrinogen deficiency, as these patients also have been shown to thrombose. This is because it has been shown that it does not require much fibrinogen to form a thrombus in the presence of red blood cells and platelets, as the platelet surface is coated with fibrinogen and, in some clinical situations, the red blood cells are also coated with minute quantities of fibrinogen.
Heptest FIBRINOTEST-Equine fibrinogen assay:
* Fast, accurate and meaningful results in
less than two minutes
* Point-of-care, one-step, whole blood testing
* Low cost per test, competitive pricing
* No minimum orders
* Low cost equipment for running the test
(can also be used with the ECMS)
* Dependable, reliable, easy to use
* Great addition to your on-site diagnostics
References:
"Fibrinogen has little importance for hemostasis, but is probably important as an antithrombotic. Rapid determination of the biological activity of fibrinogen is much more useful to the clinician than exact information about the quantity of circulating fibrinogen." - Veltkamp et al in: Indication, assay procedure, diagnosis and advice.
Human blood coagulation, pg. 186-190, Boerhaave Series, Leiden University Press, (1969).
